Scientist/Sr. Scientist, Biochemistry

We are seeking a highly-motivated, independently-thinking, and creative biochemist to join our team to work on our cell therapy programs.  The candidate will establish methods for manipulating and characterizing proteins and peptides in complex biological mixtures.  A strong background and hands-on experience in different protein expression systems (E. coli, mammalian, etc.) is required. Additional experience in molecular immunology, with specific emphasis in antigen processing and presentation, is strongly desired. This position requires excellent organizational and interpersonal skills.

At SQZ, we're proud of our culture and always look to grow our team with people who share our values. We:
  
  • Squeeze Together: We value teamwork, trust, and transparency as critical components for achieving our mission and exceeding our goals 
  • Question Boundaries: We’re committed to questioning the status quo and changing the world through our people and our science 
  • Zap Obstacles: We strive to be pioneers. We’re resilient when it comes to navigating challenges, anticipated or not, scientific and otherwise 

Responsibilities:
  • Develop processes for enriching proteinaceous content from complex biological mixtures or tissues 
  • Characterize the physiochemical and biochemical properties, such as solubility and immunogenicity, of enriched proteins 
  • Perform biochemical conjugations or modifications to enhance immunogenicity of proteins
  • Document work in notebooks and technical reports
  • Prepare presentations for internal and external meetings 
  • Participate in an interactive, team-oriented culture, interfacing primarily with a variety of project teams
 
Candidate Must:
  • Demonstrate excellent oral and written communication skills
  • Be able to contribute effectively in a cross-functional role
  • Work independently and as part of a team consisting of a diverse group of science and engineering professionals
  • Thrive within a fast-paced, dynamic and team-oriented start-up environment
  • Possess excellent organizational, interpersonal and problem solving skills 

Qualifications:
  • PhD in biochemistry, immunology, pharmaceutical sciences, or related discipline 
  • Expertise in extracting proteins from complex biological mixtures, tissues, or cell culture systems
  • Expertise in developing and implementing novel assays for characterizing protein trafficking activities, specifically in the context of antigen processing and presentation
  • Expertise with biochemical techniques such as SDS-PAGE, IEF, Western blot, and SEC/RP-HPLC 
  • Experience with immunoassays and enzymatic assays
  • Experience with high-resolution spectroscopic and physical methods, including LC-MS, NMR, light scattering or CD 
  • Demonstrated success with recombinant protein expression using different platforms (bacterial, mammalian, etc.) 
 
SQZ Biotechnologies is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, SQZ complies with applicable state and local laws governing nondiscrimination in employment. 

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