Senior Scientist

Senior Scientist Position available in our NY, NY office.

  • Develop, test and utilize algorithms to determine the optimal atomic-detail models for use in structure-based drug discovery using data from structural biology experiments such as x-ray crystallography and cryo-electron micrscopcopy (cryo-EM)
  • Perform real and reciprocal space fitting to electron or coulombic density maps, sampling of protein and ligand degrees and automated identification of alternative occupancies.
  • Develop new and innovative solutions for combining cryo-electron microscopy data with drug discovery
  • Collaborate with leading scientific groups to create computational solutions for extracting alternate conformations in crystallographic densities adding value to the drug discovery process
  • Develop scientific software for structural biology refinement in compiled and scripted languages
  • Build atomic models into cryo-em and xray crystallography maps
  • Apply knowledge of structural biology and structural biology refinement
  • Utilize structure-based drug discovery methodologies

Minimum Requirements:
  • Ph.D. degree in Computational Structural Biology, Chemistry, or a related field of study
  • Knowledge or experience in the following must have been gained through academic research, coursework, and/or experience: develop scientific software for structural
    biology refinement in compiled and scripted languages; build atomic models into cryo-
    em and xray crystallography maps; structural biology and structural biology refinement;
    and structure-based drug discovery methodologies

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