Senior Medicinal Chemist

Schrödinger’s mission is to revolutionize drug discovery through the use of breakthrough computational methods.  We are currently looking for outstanding individuals to join our drug discovery group and contribute to our rapidly expanding portfolio of drug discovery collaborations.

Our drug discovery group of over 80 scientists includes designers, modelers, computational chemists, medicinal chemists, crystallographers, biochemists, and biologists with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers as well as a large scale compute infrastructure. Four of the programs we’ve worked on in the past seven years have progressed into the clinic; two are still progressing through trials and two have been approved by the FDA.  

We are looking for a Senior Medicinal Chemist who will drive drug discovery projects through close collaboration with group members and application of cutting-edge computational approaches .
  • Lead drug discovery programs 
  • Implement medicinal chemistry strategies to deliver high quality clinical candidates 
  • Work in close collaboration with computational chemists and modelers on new idea generation and evaluation using the Schrödinger computational drug discovery platform
  • Contribute to evaluation of new target opportunities for Schrödinger’s drug discovery collaborations
  • Provide medicinal chemistry expertise to the Drug Discovery Group
Essential Qualifications, Skills and Experience:
  • Ph.D. in synthetic organic or medicinal chemistry with 8-10+ years of drug discovery experience in a pharmaceutical and/or biotechnology setting
  • Demonstrated strong track record in medicinal chemistry as evidenced by successful advancement of drug discovery projects
  • Deep expertise in establishing and execution of medicinal chemistry strategies across all stages of drug discovery to achieve program goals
  • Experience in structure-based drug design
  • Excellent understanding of biology, pharmacology, DMPK and ability to integrate these disciplines toward successful project advancement
  • Extensive experience in working with external chemistry teams at CRO’s 
  • Skilled at working in a dynamic multidisciplinary environment
  • Exceptional presentation and communication skills
Desired Skills and Experience:
  • Proven track record of progressing multiple compounds from hit identification to clinical candidates
  • Experience in API development and IND-enabling preclinical studies
  • Experience working in geographically distributed teams

We offer highly competitive compensation packages. Benefits include medical, dental, vision, 401(k), flexible spending account, 4+ weeks vacation, tuition reimbursement and a flexible work environment.

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, or sexual orientation. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.

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