Scientist, Discovery Biology

 Scholar Rock is a clinical-stage biopharmaceutical company focused on creating a robust pipeline of product candidates with the potential to transform the lives of patients suffering from a wide range of serious diseases, including neuromuscular disorders, cancer, fibrosis and anemia.  Our proprietary platform is built upon newly elucidated understanding of the molecular mechanisms of growth factor activation, which has led to the discovery and development of monoclonal antibodies that locally and selectively target these signaling proteins at the cellular level. 
 
Our lead product candidate, SRK-015, is a highly specific inhibitor of myostatin activation and is currently being evaluated in a Phase 2 proof-of-concept trial for the treatment of patients with Type 2 and Type 3 Spinal Muscular Atrophy (SMA). SRK-015 has received Orphan Drug Designation in both the US and EU. 
 
We are also advancing SRK-181, a highly specific inhibitor of TGFβ1 activation, into clinical development with plans to initiate a Phase 1 trial in patients with solid tumors in mid-2020. We believe SRK-181 has the potential to treat tumors resistant to checkpoint blockade therapy, such as anti-PD(L)1 antibodies. 

Summary of Position:
 
At Scholar Rock, our mission is to help patients with serious diseases and limited treatment options through cutting-edge science, innovative thinking, and a passion for discovering and developing novel therapeutics.  We are seeking an outstanding, motivated scientist with strong cell biology experience to join our research team.  This person will play a key role in establishing cell-based assays to evaluate novel therapeutic antibodies and to validate new targets.  The successful candidate will get an outstanding opportunity to experience the full scope of the drug discovery process within a dynamic and cross-functional team in the middle of the Cambridge biotech hub.
 
Position Responsibilities: 
 
  • Lead characterization of antibody drug candidates in preclinical pharmacology models and cell-based functional assays.
  • Collaborate in cross-functional project teams to move antibody candidates through the discovery process towards development candidate nomination, with a focus on TGF-beta superfamily biology.
  • Propose, develop and execute plans to validate novel targets for reaching go/no go decisions on antibody discovery efforts.
  • May act as project lead.
  • Present results in written and oral format at internal and external meetings.
  • Provide scientific input across all Scholar Rock projects.
 
Candidate Requirements:
 
  • Ph.D. in cell biology, biochemistry, molecular biology, or related field and 1-3 years of experience in drug discovery research.
  • Familiarity with disease biology and pharmacology models in the areas of fibrosis, immunology and/or oncology is highly desired.
  • Demonstrated skills of standard molecular biology techniques (i.e. quantitative PCR, Western blot, ELISAs).
  • Experience with high or medium throughput screening using cell-based assays is an advantage.
  • Ability to succeed in a small, highly collaborative, dynamic, and fast-paced drug discovery environment
  • Strong oral and written communication skills

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