Senior Translational Scientist

Scholar Rock is a clinical-stage biopharmaceutical company focused on creating a robust pipeline of product candidates with the potential to transform the lives of patients suffering from a wide range of serious diseases, including neuromuscular disorders, cancer, fibrosis and anemia.  Our proprietary platform is built upon newly elucidated understanding of the molecular mechanisms of growth factor activation, which has led to the discovery and development of monoclonal antibodies that locally and selectively target these signaling proteins at the cellular level. 
 
Our lead product candidate, SRK-015, is a highly specific inhibitor of myostatin activation and is currently being evaluated in a Phase 2 proof-of-concept trial for the treatment of patients with Type 2 and Type 3 Spinal Muscular Atrophy (SMA). SRK-015 has received Orphan Drug Designation in both the US and EU.
 
We are also advancing SRK-181, a highly specific inhibitor of TGFβ1 activation, into clinical development with plans to initiate a Phase 1 trial in patients with solid tumors in mid-2020. We believe SRK-181 has the potential to treat tumors resistant to checkpoint blockade therapy, such as anti-PD(L)1 antibodies.
 
Summary of Position:
 
We’re looking for a highly motivated Senior Scientist to join our Translational Sciences team. Working with the head of Translational Sciences, this experienced individual will be responsible for developing, implementing and executing translational research strategies to support preclinical and clinical programs across multiple disease areas.  This individual will also serve as translational research representative on R&D teams and assume ownership over activities such as implementing and executing studies to guide indication expansion strategies, identifying and validating preclinical and clinical biomarkers, and guiding FIH dose selection in early stage clinical trials  This position represents an opportunity to join a newly formed group at Scholar Rock and have influence over future growth of our Translational Sciences team while supporting multiple programs at various stages, starting from lead candidate selection to IND enabling activities and early stage clinical development. 
 
Position Responsibilities: 
  • Apply expertise in drug discovery and preclinical development to influence overall translational research strategy and project progression.
  • Propose and lead preclinical studies to investigate relationships between efficacy, pharmacokinetics and pharmacodynamic endpoints.
  • Contribute to the overall biomarker strategy for clinical trial support, including identification and validation of biomarkers in preclinical studies and translate preclinical outcomes into clinical assays.
  • Utilize in vitro and in vivo platforms such as imaging, flow cytometry, IHC, RNA-seq to understand mechanism of action, identify and validate pharmacodynamic markers to support preclinical and clinical development plans.
  • Independently design, execute, analyze and present data from in vivo efficacy and PK/PD studies.
  • Effectively manage both internal and external work, including interactions with academic collaborators, external CROs and other vendors.
  • Serve as translational research lead on cross-functional preclinical and clinical project teams; collaboratively contributing to the design, plan and execution of multiple preclinical studies/activities

  • Communicate scientific progress to company leadership and key stakeholders.

Requirements:
  • Ph.D. in biomedical research with an emphasis on cell biology and/or pharmacology
  • 5+ years of research experience in pharmaceutical drug discovery and/or pharmacology, with proven track record in advancing drug candidates through preclinical development.
  • Experience in disease areas relevant to Scholar Rock a strong plus; familiarity with oncology and immuno-oncology highly desirable
  • Experience and/or working knowledge of a range of in vitro and ex vivo assay methods that can be applied to cells or biological samples obtained in preclinical or clinical settings, including multiparameter flow cytometry, human primary immune cell assays. 
  • Experience working with teams in support of preparing documents and reports for internal governance committees and regulatory agencies, including INDs.
  • Strong interpersonal, influencing, problem solving and negotiating skills, together with evidence of having used these to support collaboration(s); both within an organization and/ or external partners
  • Ability to prioritize and manage multiple tasks simultaneously while keeping to timelines and milestone projections.

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