Scientist - Immunology

Scholar Rock is a clinical-stage biopharmaceutical company focused on creating a robust pipeline of product candidates with the potential to transform the lives of patients suffering from a wide range of serious diseases, including neuromuscular disorders, cancer, fibrosis and anemia.  Our proprietary platform is built upon newly elucidated understanding of the molecular mechanisms of growth factor activation, which has led to the discovery and development of monoclonal antibodies that locally and selectively target these signaling proteins at the cellular level. 

Our lead product candidate, SRK-015, is a highly specific inhibitor of myostatin activation and is currently being evaluated in a Phase 2 proof-of-concept trial for the treatment of patients with Type 2 and Type 3 Spinal Muscular Atrophy (SMA). SRK-015 has received Orphan Drug Designation in both the US and EU.

We are also advancing SRK-181, a highly specific inhibitor of TGFβ1 activation, into clinical development with plans to initiate a Phase 1 trial in patients with solid tumors in mid-2020. We believe SRK-181 has the potential to treat tumors resistant to checkpoint blockade therapy, such as anti-PD(L)1 antibodies.
 
Summary of Position:
 
Scholar Rock is seeking an outstanding individual with immunology experience to join our research team.  We’re looking for someone who’s interested in working on novel approaches to tackling difficult diseases in which the immune system is involved.  You will be involved in identifying and validating new immune targets across diseases.  You will also be responsible for the characterization of novel antibodies that specifically modulate the function of disease-causing mediators in the space of immuno-oncology and immunology.
  
Position Responsibilities: 
  • Independent execution, documentation, and analysis of immunological and cell biological in vitro and ex vivo screening assays and mechanistic studies.
  • Execute a broad range of assays, including flow cytometry and sorting, cell-based and immune function/response assays and reporter assays to support in vitro and in vivo model development. 
  • Contribute to conceptualizing, building and potentially leading new target programs in immunology and supporting current immunology teams.
  • Maintain detailed records of experimental protocols and data in laboratory notebooks in accordance with company policy.
  • Analyze, interpret and report experimental results in small group settings and company-wide meetings.
 
Candidate Requirements:
  • BA/BS or MS in biology, immunology, pharmacology or related field with a minimum of 5 years of industry experience, or Ph.D in a related field. 
  • Experience designing ex vivo and in vitro immunological and cell based assays to assess activity of therapeutics is desired.
  • Strong desire and aptitude to take a co-lead role on future programs.
  • Skilled in standard immunological, molecular and cell biology techniques including multi-color flow cytometry, ELISAs, RTPCR and primary immune cell isolation and culture from a variety of sources.
  • Prior work with in vivo models of immune-related diseases or oncology is desired.
  • Prior work with antibodies and biologics is a plus.
  • Strong written and verbal communication skills.
  • The individual should be able to function in a timeline-driven, dynamic environment, and be able to rapidly adapt to new techniques and protocols. A strong work ethic and high-level motivation are required. The successful candidate should have the ability to work both independently and as part of a team to meet deadlines and contribute to the strategic goals of the company.
 
Scholar Rock is an Equal Opportunity Employer.  We celebrate diversity and are committed to creating an inclusive environment for all employees.

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