Senior Computational Biologist - Assay Development

What is Freenome?
Freenome is a health technology company bringing accurate, accessible and non-invasive disease screenings to you and your doctor to proactively treat cancer and other diseases at their most manageable stages. Freenome is a place where you can do your best, most meaningful work, and contribute to a whole new way of thinking about curing cancer. It’s a data-driven, diverse company at the intersection of biology, technology and medicine.

Our Mission
Equip you and your family with knowledge and tools to maintain a healthier life and prevent disease.

About the Role
The computational biology team at Freenome plays a key role in integrating our unique laboratory technology and novel machine learning efforts by supporting assay and model development and transforming raw data into maximally useful forms for machine learning.

As a computational biologist in assay development at Freenome, you will be an integral part of our R&D team, working in collaboration with molecular biologists to develop new assay technologies measuring human health to produce data for our machine learning engine, driving Freenome’s mission of early detection and intervention in human disease.

  • Develop new assay technologies in collaboration with molecular biologists to optimize signal recovery, reliability, and COGS on a variety of assays and analytes.
  • Develop novel bioinformatics workflows and take them from prototyping in R&D to production in a high-throughput environment.

What We're Looking For
  • PhD (or equivalent research experience) in computational biology, bioinformatics, cancer biology, genomics, or a related field
  • Extensive experience working with raw next-generation sequencing data in collaboration with molecular biologists to develop new molecular assays
  • Deep knowledge of analysis and QC procedures for development of new NGS-based molecular assays.
  • Proficiency in at least one general-purpose programming language: Python, Java, C++, etc.
  • Proficiency in a scientific data processing ecosystem: R, Python/Numpy, etc
  • Knowledge of statistics as applied to assay development and evaluation: significance testing, Bayes’ theorem, application of basic probability distributions used in computational biology.
  • Skilled at clearly communicating scientific results with a team and working collaboratively towards next steps

Nice to Haves
  • 3+ years postdoctoral work in academia or equivalent industry experience demonstrating success in leading development projects.
  • Bench experience: you’ve analyzed data you generated. 
  • Experience working with NGS data beyond diploid germline DNA-seq: cfDNA, RNA-seq, single-cell sequencing, metagenomics, epigenomics, etc
  • Experience working with non-NGS based assay development: PCR and proteomic technologies
  • Experience with software engineering best practices: code quality, testing, performance optimization, development of research tools infrastructure.
  • Experience implementing bioinformatics workflows in traditional HPC like SGE, SLURM, LSF, PBS, etc.
  • Experience implementing bioinformatics workflows in cloud-/container-based environments like AWS, Google Cloud, Docker, Kubernetes

Freenome’s Culture
Our culture is simple. We value Empathy, Trust and Integrity. We feel from the perspectives of each other, patients and the communities we serve. We give each other the benefit of the doubt and believe we’re all working as a team towards our goals. We conduct ourselves with integrity, empowering others to grow in a collaborative environment. Freenome explicitly  prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

What does a successful person look like at Freenome?
You can prioritize, manage and execute your goals and align them to the mission of Freenome. You’re a steward of the culture and hold yourself and the team accountable. You believe hiring and mentorship are fundamental to building the organization. You bring ownership to your role, focus on your process and find the gaps to help Freenome reach its full potential. You welcome feedback and criticism knowing its value is to build people up and support each other, rather than tearing each other down.