Scientist/Sr. Scientist, Cell and Gene Therapy Research

Position Summary
Working within Fractyl’s Cell and Gene Therapy research team, the Scientist/Senior Scientist is responsible for contributing to the company’s pipeline programs with primary focus on designing and developing molecular assays and viral technologies. Successful candidates will be integral to discovering and developing the next generation of cell and gene therapies centered on treating unmet needs due to metabolic disease. With a desire to overcome obstacles, the Scientist/Sr. Scientist will drive the program forward and ensure timely, effective and efficient delivery of program goals.  In close collaboration with team members, the individual will participate in cross-team efforts and manage external partners as appropriate. 
 
Primary Responsibilities
  • Contribute to the cell and gene therapy program to engineer and characterize intestinal stem cells of the GI-tract with properties that elicit important biological effects for disease targets.
  • Design, optimize, and characterize methodologies for engineering intestinal stem cells using viral technologies or similar strategies to elicit important biological effects.
  • Characterize endogenous and transgene expression in vitro and in vivo.
  • Identify and bring to Fractyl new technologies to support the goals of the cell and gene therapy objectives.
  • Drive forward program goals to meet team objectives, working closely with CROs and internal teams.
  • Manage CRO activities, executing the molecular and cellular biology program goals (in vitro).
  • Bring a “can do” spirit to work and deliver on other responsibilities as assigned.
 
Education or Certification Requirements
  • PhD or Masters with equivalent industry experience in a highly-related research field.
 
Professional Work Experience
  • Experience in biotech and/or pharmaceutical industries preferred but not required
  • PhD with 2 years of industry experience inclusive of viral technology experience; OR
  • Masters with 8+ years of industry experience in a highly-related research field.
 
Qualifications and Skills
  • Extensive experience with the design, validation, and running of molecular assays to detect gene expression, viral titer, and viral copy number analysis
  • Expertise in viral technologies, such as lentivirus, AAV, adenovirus, including vector design, viral production and characterization, and transduction of mammalian cells both in vitro and in vivo
  • Experience with mammalian cell culture, cell transfection, and cell transduction
  • Experience or willingness to work with small and large animal models as needed to drive forward program goals
  • Familiarity with a variety of molecular and cellular biology techniques, with the ability to learn, troubleshoot, and execute for the goals of the team
  • Track record of challenging oneself to enhance scientific abilities
 
Other Essentials and Key Success Factors
  • Successful track record of working in high-growth and dynamic organizations
  • Demonstrated record of intellectual curiosity, innovation and creative problem solving with an entrepreneurial spirit
  • Ability to lead fast-paced projects with a keen sense of urgency to get the job done well
  • Evidence of "hands-on" experience and expertise
  • Proven and successful track record as a team-player and collaborator in small working environments
  • Self-motivated and the ability to work independently while working towards common team goals
  • Highly organized and detail oriented with a passion to deliver quality results
  • Excellent verbal and written communication skills, with experience translating technical concepts into user-friendly documentation
  • Highest levels of professionalism, confidence, personal values and ethical standards
 
Travel
  • Up to 5% nationally
 
The description and requirements outlined above are general; additional requirements may apply.

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